Château la Mission Haut-Brion is a Bordeaux wine from the Pessac-Léognan appellation, classed among the Grand Crus in the Graves classification of 1953. The winery, located in close vicinity of the city of Bordeaux, belongs to the wine region Graves, in the commune of Pessac with additional property in Talence.

The château also produces a second wine from younger vines, La Chapelle de la Mission, since the 1991 vintage, and the dry white wine Château La Mission

Haut-Brion Blanc since the Merger of Château Laville Haut-Brion. After the death of Henri Woltner in 1974 and his brother shortly after, the estate was run by Françoise Woltner and Francis DeWavrin, daughter and son-in-law of Fernand Woltner.

Though standards were maintained, family discord led to the sale of the estate, along with La Tour Haut-Brion and Laville Haut-Brion in 1983,[to Domaine Clarence Dillon, owners of Château Haut-Brion since 1935while the DeWavrins moved on to run Chateau Woltner in Howell Mountain AVA. Although the historical competition between Haut-Brion and La Mission has been absent in recent years, through the supervision of manager Jean-Bernard Delmas, and later Jean-Philippe Delmas, the original terroir of the vineyards has been upheld and La Mission has remained distinctive.

American wine critic Robert Parker awarded the maximum one hundred points for the 2006 La Mission Haut Brion,making it six occasions Parker has given the estate this score. Jancis Robinsonn, MW describes La Mission as "the quintessential insider's wine"while David Peppercorn, MW holds the estate's consistent performance over the last century as justification to classify La Mission as a Premier Cru, as was done to Château Mouton Rothschild in 1973. In 2009, the Liv-ex Bordeaux Classification considered Château La Mission Haut-Brion as a potential First Growth along the five estates classified in 1855, château Haut-Brion, château Margaux, château Lafite-Rothschild, château Latour et châton Mouton-Rothschild

Appellation: Pessac-Léognan
Areas under Vine: 21 hectares
Average Annual Production: 7,000 Cases
Grape Varieties: 48% Cabernet Sauvignon, 45% Merlot, and 7% Cabernet Franc.
Ageing: In 90% oak barrels for 16 to 18 months